DISC1: A Schizophrenia Gene with Multiple Personalities
نویسندگان
چکیده
منابع مشابه
DISC1: A Schizophrenia Gene with Multiple Personalities
Two papers address the contribution of DISC1 to neural development and schizophrenia risk in this issue of Neuron. These complementary studies elegantly bridge the gap between genetic and cellular studies of schizophrenia, providing a level of functional validation that is often lacking in the field.
متن کاملAssociation study between schizophrenia and the DISC1 gene polymorphism
Abstract Background: The disrupted-in-schizophrenia 1 (DISC1) gene, on the chromosome position 1q42, was initially identified at the breakpoint of a balanced translocation, t(1,11)(q42.1q14.3), which segregated with major mental disorders in a large Scottish family. Methods: Our samples included 200 unrelated patients diagnosed with Schizophrenia on the basis of DSM-IV criteria an...
متن کاملassociation study between schizophrenia and the disc1 gene polymorphism
abstract background: the disrupted-in-schizophrenia 1 (disc1) gene, on the chromosome position 1q42, was initially identified at the breakpoint of a balanced translocation, t(1,11)(q42.1q14.3), which segregated with major mental disorders in a large scottish family. methods: our samples included 200 unrelated patients diagnosed with schizophrenia on the basis of dsm-iv criteria and 200 norm...
متن کاملExpression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs.
DISC1 has been identified as a schizophrenia susceptibility gene based on linkage and SNP association studies and clinical data suggesting that risk SNPs impact on hippocampal structure and function. In cell and animal models, C-terminus-truncated DISC1 disrupts intracellular transport, neural architecture and migration, perhaps because it fails to interact with binding partners involved in neu...
متن کاملSeryl-tRNA Synthetases: Enzymes with Multiple Personalities*
Seryl-tRNA synthetases (SerRS) are essential enzymes responsible for aminoacylation of cognate transfer-RNAs (tRNAs) with serine, which is then incorporated into the proteins being synthesized on the ribosome. Although tRNA synthetases are usually a very conserved class of enzymes, phylogenic analyses revealed the existence of two distinct types of serine-charging enzymes; a standard or bacteri...
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ژورنال
عنوان ژورنال: Neuron
سال: 2011
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2011.10.023